Chen is a professor of immunology at the Yale Sch

ool of Medicine. He was the first scientist to reveal the function

of the PD-L1/PD-1 immune escape pathway in a tumor’s microenvironment.

The programmed death ligand-1/programmed death-1 (PD-L1/PD-1) signaling pathway is a key component of tumor immu

nosuppression, which can inhibit activation of T lymphocytes and enhance immune tolerance of tumor cel

ls, leading to tumor immune escape, according to a study published in January on biomedcentral.com.

Chen, along with four other scientists, was awarded the Warren Alpert Foundation Prize for 2017 for the break

through in tumor immunology, which made him the third Chinese recipient of the prize.

Chen said the research environment in China also has improved in terms of govern

ment funding and talent compared with when he was in China three decades ago.

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